Type Of Media：学術論文
Publication/Magazine/Media：Journal of Controlled Release
Author：Anjaneyulu Dirisala, Satoshi Uchida, Kazuko Toh, Junjie Li, Xueying Liu, Panyue Wen, Shigeto Fukushima and Kazunori Kataoka
Structural stability and RNase resistance of mRNA Polyplex micelles for systemic delivery
- Polyplex micelles (PMs) are structurally stable in vitro and in mouse bloodstream.
- RNases degrade mRNA inside PMs in vitro and in mice, even without PM dissociation.
- This study identifies key design factors of PMs for protection from RNases.
- Polycation structure and length are determinants of RNase stability of PMs.
- Enhancing RNase resistance remains challenging for systemic delivery of PMs
https://doi.org/10.1016/j.jconrel.2025.113935
