Type Of Media：海外Web媒体
Publication/Magazine/Media：e cancer
Cellular immunity of "comb-structured mRNA" as a novel cancer mRNA vaccine
The Kawasaki Innovation Center for NanoMedicine (iCONM; Director: Kazunori Kataoka; Location: Kawasaki, Japan) have announced with Tokyo Medical and Dental University, and Kyorin University that a group led by Prof. Satoshi Uchida, Principal Research Scientist of iCONM (Professor, Department of Advanced Nanomedical Engineering, Medical Research Institute, Tokyo Medical and Dental University), has developed a novel mRNA derivative and demonstrated its high cellular immunity inducing anti-cancer activities in mice model. This novel mRNA, with comb-like structure, has double-stranded RNA in the shape of comb teeth, activates immune cells, and demonstrates high anti-tumor effects in experiments using melanoma and lymphoma model mice. The paper, titled "Comb-structured mRNA vaccine tethered with short double-stranded RNA adjuvants maximizes cellular immunity for cancer treatment," was published online in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) dated on July 10, 2023.
http://doi.org/10.1073/pnas.2214320120
